ApoE4 - Wiki (boutique)

ApoE4

Contents

• 1 About this wiki
• 2 Introduction
• 3 Encouraging ApoE4 research
• 4 Interesting Alzheimer's research projects
• 5 Possible modulators of ApoE4-associated pathology
  
  • 5.1 Coffee (and caffeine)
  • 5.2 Omega-3 (n-3) fatty acids
  • 5.3 Alcohol consumption
  • 5.4 Turmeric and curcumin
  • 5.5 Blood Sugar
  • 5.6 Coconuts and coconut products
  • 5.7 Inflammation and LPS (lipopolysaccharides)
• 6 Biomarkers
• 7 Resources -- Events
• 8 Resources -- learning more about APOE
• 9 Resources -- where to buy supplements, olive oil, etc.
• 10 Resources -- APOE-aware healthcare practitioners
• 11 Notes

About this wiki

This wiki was created in order to organize information about how to
prevent and treat ApoE4-associated pathology. (See Notes, below, for
rationale.) As of early 2014, the page is still very much under
construction, but much more information will be added in the coming
weeks and months -- especially if you, the reader, contribute! Visit the wiki development forum at apoe4.info
if you have questions about how to contribute or ideas about how these
pages should be organized. (Or click on the "Discussion" tab above for
thoughts specific to this introductory page.)

Introduction

The ε4 variant of the APOE gene is famous for conferring a significantly higher risk for Alzheimer's disease, but numerous other diseases have been linked to it, including, to name a few, other forms of dementia,
heart disease, and gallbladder stones. Much of the focus of this wiki
space will nonetheless likely be on Alzheimer's disease and other forms
of dementia, since dementia is what most ε4 carriers are concerned
about, given the devastating consequences of dementia and the current
lack of effective treatment for it.



While the focus of the wiki will be on illness and its prevention and treatment, it should be noted that possessing an APOE-ε4 allele
is not an entirely bad thing for health. A few minor health advantages
seem to be conferred by ApoE4, among them, greater absorption or
production via sunlight of vitamin D, resistance to malnutrition in
children with conditions causing frequent diarrhea [1], protection against severe liver disease caused by hepatitis C [2], and slightly greater intelligence in youth [3].